Skip to Content


No results


No results


No results

Search Results


No results
Search events using: keywords, sponsors, locations or event type
When / Where
All occurrences of this event have passed.
This listing is displayed for historical purposes.

Presented By: Center for RNA Biomedicine

RNA Innovation Seminar: Shuying Sun, Johns Hopkins University

RNA Metabolism in C9ORF72-linked neurodegenerative diseases ALS and FTD

Shuying Sun Shuying Sun
Shuying Sun
In-person: BSRB, ABC seminar rooms

Abstract: We have a long-standing interest in RNA metabolism dysfunction and RNA-targeting therapy in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The hexanucleotide GGGGCC repeat expansion in C9ORF72 is the most frequent genetic cause of both ALS and FTD. RNA-mediated gain of toxicity is critical for the pathogenesis. We employ multiple molecular approaches to understand the regulation of the repeat RNA processing, uncover genetic modifiers, and elucidate the influence on global RNA metabolism. We aim to understand the disease mechanisms and identify potential therapeutic targets for C9ORF72-ALS/FTD.
Shuying Sun Shuying Sun
Shuying Sun

Co-Sponsored By

Explore Similar Events

  •  Loading Similar Events...

Back to Main Content