Presented By: Biomedical Engineering
Biomedical Engineering Seminar Series
"The adaptive immune system and senescence in regenerative medicine," with Jennifer Elisseeff, PhD
Abstract:
There are profound deficits in how humans, and adults in particular, heal and recover from tissue damage. The alternative to productive tissue healing is the formation of dysfunctional scaring, which underlies chronic degenerative arthritic conditions, chronic autoimmune diseases and the fibrosis associated with the foreign body response to implants. Our clinical translation experiences in orthopedics and plastic surgery yielded the unexpected discovery of adaptive immune cells in the biomaterial response. Distinct pathways of adaptive immunity, T cells together with linked activity of innate lymphocytes, regulate productive versus destructive tissue responses and should therefore be the primary targets of regenerative medicine. Recent data further implicate cellular senescence as a major therapeutically targetable player in local tissue-destructive immune responses and fibrosis. Understanding and subsequent manipulation of the local tissue microenvironment with regenerative immunotherapies and biomaterials is a mechanism by which the effector class and T cell function and senescence can be engaged. We are now working to understand the role of the immune system and cellular senescence in the biomaterial response and repair across different tissues across lifespan.
Bio:
Dr. Elisseeff is the Morton Goldberg Professor and Founder of the Translational Tissue Engineering Center at Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute and is Interim Chair of the Department of Chemical and Biomolecular Engineering. She was elected a Fellow of the American Institute of Medical and Biological Engineering, the National Academy of Inventors, a Young Global Leader by World Economic Forum. In 2018, she was elected to the National Academy of Engineering and National Academy of Medicine and in 2019 she received the NIH Directors Pioneer Award. In 2022 she was elected as a fellow of the American Academy of Arts and Sciences and in 2023 a member of the National Academy of Sciences.
Zoom:
https://umich.zoom.us/j/99085426766
There are profound deficits in how humans, and adults in particular, heal and recover from tissue damage. The alternative to productive tissue healing is the formation of dysfunctional scaring, which underlies chronic degenerative arthritic conditions, chronic autoimmune diseases and the fibrosis associated with the foreign body response to implants. Our clinical translation experiences in orthopedics and plastic surgery yielded the unexpected discovery of adaptive immune cells in the biomaterial response. Distinct pathways of adaptive immunity, T cells together with linked activity of innate lymphocytes, regulate productive versus destructive tissue responses and should therefore be the primary targets of regenerative medicine. Recent data further implicate cellular senescence as a major therapeutically targetable player in local tissue-destructive immune responses and fibrosis. Understanding and subsequent manipulation of the local tissue microenvironment with regenerative immunotherapies and biomaterials is a mechanism by which the effector class and T cell function and senescence can be engaged. We are now working to understand the role of the immune system and cellular senescence in the biomaterial response and repair across different tissues across lifespan.
Bio:
Dr. Elisseeff is the Morton Goldberg Professor and Founder of the Translational Tissue Engineering Center at Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute and is Interim Chair of the Department of Chemical and Biomolecular Engineering. She was elected a Fellow of the American Institute of Medical and Biological Engineering, the National Academy of Inventors, a Young Global Leader by World Economic Forum. In 2018, she was elected to the National Academy of Engineering and National Academy of Medicine and in 2019 she received the NIH Directors Pioneer Award. In 2022 she was elected as a fellow of the American Academy of Arts and Sciences and in 2023 a member of the National Academy of Sciences.
Zoom:
https://umich.zoom.us/j/99085426766
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