Presented By: Biomedical Engineering
Biomedical Engineering Seminar Series
Cardiovascular 2D to 5D Flow MRI, featuring Michael Markl, PhD
Abstract:
The intrinsic motion sensitivity of magnetic resonance imaging (MRI) can be used acquire and quantify blood flow in-vivo. Advances in imaging techniques allow the use of 4D flow MRI to measure, visualize and quantify 3D blood flow with full volumetric coverage of cardiac chambers or cardio- or neurovascular regions (e.g., thoracic aorta, large cerebral vessels). The complexity of the 4D flow MRI data (3 spatial dimension, 3 velocity directions, time) allows for the visualization of complex 3D blood flow patterns and the retrospective quantification of blood flow and derived hemodynamic parameters (e.g., wall shear stress, pressure gradients) which has facilitated insight into cardiovascular hemodynamics previously limited by other in-vivo imaging strategies. Specifically, quantitative flow analysis can provide information on the impact of cardio- or neurovascular pathologies on altered hemodynamics associated with disease progression and patient outcome.
This presentation will 1) introduce methodological aspects of 2D flow imaging with MRI and the state-of-the-art and recent developments related to 4D flow MRI; 2) describe clinical applications of cardiothoracic 4D flow MRI for the assessment of 3D flow dynamics in the heart and vessels that have demonstrated its potential for an improved assessment of cardiovascular disease, and 3) discuss recent developments such as 5D flow imaging and application of artificial intelligence and deep learning for improved analysis workflows.
Bio:
Dr. Markl is the Vice Chair for Research in the Department of Radiology at Northwestern University Feinberg School of Medicine. He is also the Lester B. and Frances T. Knight Professor of Cardiac Imaging in the Departments of Radiology and Biomedical Engineering at Northwestern University. He received his PhD in Physics from the University of Freiburg, Germany (2000), and served as a postdoctoral fellow at the Lucas MRI/S Center at Stanford University, Radiology (2001-2004). In 2004, he returned to the University Hospital in Freiburg, Germany as the Director of Cardiovascular MRI. Dr. Markl joined the Northwestern Radiology and BME faculty in 2011.
Dr. Markl's research program has had a major impact on the diagnosis and management of cardiovascular disease including the development of novel imaging techniques for the assessment of cardiac structure, function and hemodynamics, and discovery of mechanisms underlying cardiovascular diseases development and stroke. He is internationally recognized as the pioneer of 4D flow MRI and work in this area has advanced the understanding of cardiovascular disease processes as well as enhanced patient care.
To date, his accomplishments include a total of >380 peer-reviewed publications, 800+ conference abstracts, 29 invited review articles, 5 clinical guideline or consensus statement documents, 11 book chapters, 13 patents, and >180 invited presentation. In addition, Dr. Markl has a track-record of external funding with over 40 awarded grants from the NIH, societies, and industry collaborations. He has a record of mentorship having trained over 90 medical and graduate students, postdocs, clinical fellows, and junior faculty. These trainees have received prestigious awards from the NIH, AHA, ISMRM, RSNA, and others and have successful careers in academia and industry.
Dr. Markl is a recipient of the RSNA Research Trainee Prize, the I.I. Rabi Award Young Investigator Award of the ISMRM, and the Distinguished Investigator Award of the Academy of Radiology Research. He is an Associate Editor for 'Radiology - Cardiothoracic Imaging’, a Fellow of the ISMRM and SCMR, a member of the Executive Committee of the Board of Trustees (Vice-President) of the SCMR, and the Past-President-of the SMRA.
The intrinsic motion sensitivity of magnetic resonance imaging (MRI) can be used acquire and quantify blood flow in-vivo. Advances in imaging techniques allow the use of 4D flow MRI to measure, visualize and quantify 3D blood flow with full volumetric coverage of cardiac chambers or cardio- or neurovascular regions (e.g., thoracic aorta, large cerebral vessels). The complexity of the 4D flow MRI data (3 spatial dimension, 3 velocity directions, time) allows for the visualization of complex 3D blood flow patterns and the retrospective quantification of blood flow and derived hemodynamic parameters (e.g., wall shear stress, pressure gradients) which has facilitated insight into cardiovascular hemodynamics previously limited by other in-vivo imaging strategies. Specifically, quantitative flow analysis can provide information on the impact of cardio- or neurovascular pathologies on altered hemodynamics associated with disease progression and patient outcome.
This presentation will 1) introduce methodological aspects of 2D flow imaging with MRI and the state-of-the-art and recent developments related to 4D flow MRI; 2) describe clinical applications of cardiothoracic 4D flow MRI for the assessment of 3D flow dynamics in the heart and vessels that have demonstrated its potential for an improved assessment of cardiovascular disease, and 3) discuss recent developments such as 5D flow imaging and application of artificial intelligence and deep learning for improved analysis workflows.
Bio:
Dr. Markl is the Vice Chair for Research in the Department of Radiology at Northwestern University Feinberg School of Medicine. He is also the Lester B. and Frances T. Knight Professor of Cardiac Imaging in the Departments of Radiology and Biomedical Engineering at Northwestern University. He received his PhD in Physics from the University of Freiburg, Germany (2000), and served as a postdoctoral fellow at the Lucas MRI/S Center at Stanford University, Radiology (2001-2004). In 2004, he returned to the University Hospital in Freiburg, Germany as the Director of Cardiovascular MRI. Dr. Markl joined the Northwestern Radiology and BME faculty in 2011.
Dr. Markl's research program has had a major impact on the diagnosis and management of cardiovascular disease including the development of novel imaging techniques for the assessment of cardiac structure, function and hemodynamics, and discovery of mechanisms underlying cardiovascular diseases development and stroke. He is internationally recognized as the pioneer of 4D flow MRI and work in this area has advanced the understanding of cardiovascular disease processes as well as enhanced patient care.
To date, his accomplishments include a total of >380 peer-reviewed publications, 800+ conference abstracts, 29 invited review articles, 5 clinical guideline or consensus statement documents, 11 book chapters, 13 patents, and >180 invited presentation. In addition, Dr. Markl has a track-record of external funding with over 40 awarded grants from the NIH, societies, and industry collaborations. He has a record of mentorship having trained over 90 medical and graduate students, postdocs, clinical fellows, and junior faculty. These trainees have received prestigious awards from the NIH, AHA, ISMRM, RSNA, and others and have successful careers in academia and industry.
Dr. Markl is a recipient of the RSNA Research Trainee Prize, the I.I. Rabi Award Young Investigator Award of the ISMRM, and the Distinguished Investigator Award of the Academy of Radiology Research. He is an Associate Editor for 'Radiology - Cardiothoracic Imaging’, a Fellow of the ISMRM and SCMR, a member of the Executive Committee of the Board of Trustees (Vice-President) of the SCMR, and the Past-President-of the SMRA.
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