Presented By: Single Cell Spatial Analysis Program (SCSAP)
Single Cell Spatial Analysis Monthly Seminar Series
"Spatial Multi-omics Reveals the Role of Wnt Signaling Modulators in Cleft Palate" Featuring: Jeremie Oliver Piña, Ph.D., M.S., M.B.A.
Join us Monday, October 14th for our next seminar featuring: Jeremie Oliver Piña, Ph.D., M.S., M.B.A., Post-Doctoral Fellow/NICHD/NIH
ABSTRACT: Multiple genetic and environmental etiologies contribute to the pathogenesis of cleft palate, which constitutes the most common among the inherited disorders of the craniofacial complex. Insights into the molecular mechanisms regulating osteogenic differentiation and patterning in the palate during embryogenesis are limited and needed for the development of innovative diagnostics and cures. Recently, we defined the transcriptomic basis of murine secondary palate development using bulk, single-cell, and whole-transcriptome spatial RNA-sequencing. This multimodal approach enabled the identification of several novel enriched genes at specific developmental time points. Wnt signaling modulators influence osteogenic programming during palate formation, potentially contributing to the observed cleft palate phenotype. These modulators of developmental signaling may prove to be viable diagnostic and/or therapeutic targets to augment palatal bone during surgical or minimally invasive interventions for cleft palate.
ABSTRACT: Multiple genetic and environmental etiologies contribute to the pathogenesis of cleft palate, which constitutes the most common among the inherited disorders of the craniofacial complex. Insights into the molecular mechanisms regulating osteogenic differentiation and patterning in the palate during embryogenesis are limited and needed for the development of innovative diagnostics and cures. Recently, we defined the transcriptomic basis of murine secondary palate development using bulk, single-cell, and whole-transcriptome spatial RNA-sequencing. This multimodal approach enabled the identification of several novel enriched genes at specific developmental time points. Wnt signaling modulators influence osteogenic programming during palate formation, potentially contributing to the observed cleft palate phenotype. These modulators of developmental signaling may prove to be viable diagnostic and/or therapeutic targets to augment palatal bone during surgical or minimally invasive interventions for cleft palate.
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Livestream Information
ZoomOctober 14, 2024 (Monday) 1:00pm
Meeting ID: 99872594985
Meeting Password: 786053
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