The LUX-ZEPLIN (LZ) experiment is primarily designed to search for rare interactions between ordinary matter and galactic dark matter particles. The experiment employs a 7-tonne liquid xenon time-projection chamber surrounded by a three component veto system: a liquid-xenon skin, a nearly-hermetic Gd-loaded liquid scintillator, and an instrumented tank of ultra-pure water. In this talk I will present new results from LZ’s search for dark matter using a 4.2 tonne-year exposure of the instrument, comprising the largest search exposure from a dark matter direct detection experiment to date.