Presented By: Biomedical Engineering
Alan J. Hunt Memorial Lecture-U-M Biomedical Engineering
Suzie Pun, Ph.D., Washington Research Foundation Professor of Bioengineering, Director for the Molecular Engineering and Sciences Institute, and Associate Director of the Resuscitation Engineering Science Unit (RESCU), University of Washington
Engineering synthetic alternatives to biologics for medicine
Abstract:
Biologics, products produced from living organisms, have revolutionized treatment of disease. Examples of FDA-approved biologics include therapeutic proteins (e.g. blood clotting factors and antibodies), engineered viruses for gene therapy, and cell therapies. Biologics are addressing previous unmet medical needs, but are challenging to manufacture and therefore high in cost. In this talk, I will describe our efforts to develop synthetic alternatives to biologics used in medicine. In the first example, we develop synthetic polymers that facilitate hemostasis and resuscitation for trauma medicine. In a second example, we synthesize a polymer that facilitates intracellular delivery of biologic cargo synthesized based on design principles learned from adenoviral vectors. In a final example, we identify unique aptamers to replace antibodies used in cell therapy manufacturing.
Bio:
Suzie H. Pun is the Washington Research Foundation Professor of Bioengineering, Director for the Molecular Engineering and Sciences Institute, and Associate Director of the Resuscitation Engineering Science Unit (RESCU) at University of Washington. She is a fellow of the U.S. National Academy of Inventors (NAI) and American Institute of Medical and Biological Engineering (AIMBE), and has been recognized with MIT Technology Review’s “Top 100 Young Innovators” designation, the Presidential Early Career Award for Scientists and Engineers, and as an AAAS-Lemelson Invention Ambassador. She was also recognized with the University of Washington’s Marsha Landolt Distinguished Graduate Mentor Award for her dedicated mentoring of students. She currently serves as an Associate Editor for ACS Biomaterials Science and Engineering and on the Science Board of Reviewing Editors.
Suzie Pun received her B.S. in Chemical Engineering from Stanford University and her Ph.D. in Chemical Engineering from the California Institute of Technology. She also worked as a senior scientist at Insert Therapeutics/Calando Pharmaceuticals developing polymeric drug delivery systems before joining the Department of Bioengineering at University of Washington. Her current work focuses on biomaterial applications in drug delivery and gene and cell therapy.
Abstract:
Biologics, products produced from living organisms, have revolutionized treatment of disease. Examples of FDA-approved biologics include therapeutic proteins (e.g. blood clotting factors and antibodies), engineered viruses for gene therapy, and cell therapies. Biologics are addressing previous unmet medical needs, but are challenging to manufacture and therefore high in cost. In this talk, I will describe our efforts to develop synthetic alternatives to biologics used in medicine. In the first example, we develop synthetic polymers that facilitate hemostasis and resuscitation for trauma medicine. In a second example, we synthesize a polymer that facilitates intracellular delivery of biologic cargo synthesized based on design principles learned from adenoviral vectors. In a final example, we identify unique aptamers to replace antibodies used in cell therapy manufacturing.
Bio:
Suzie H. Pun is the Washington Research Foundation Professor of Bioengineering, Director for the Molecular Engineering and Sciences Institute, and Associate Director of the Resuscitation Engineering Science Unit (RESCU) at University of Washington. She is a fellow of the U.S. National Academy of Inventors (NAI) and American Institute of Medical and Biological Engineering (AIMBE), and has been recognized with MIT Technology Review’s “Top 100 Young Innovators” designation, the Presidential Early Career Award for Scientists and Engineers, and as an AAAS-Lemelson Invention Ambassador. She was also recognized with the University of Washington’s Marsha Landolt Distinguished Graduate Mentor Award for her dedicated mentoring of students. She currently serves as an Associate Editor for ACS Biomaterials Science and Engineering and on the Science Board of Reviewing Editors.
Suzie Pun received her B.S. in Chemical Engineering from Stanford University and her Ph.D. in Chemical Engineering from the California Institute of Technology. She also worked as a senior scientist at Insert Therapeutics/Calando Pharmaceuticals developing polymeric drug delivery systems before joining the Department of Bioengineering at University of Washington. Her current work focuses on biomaterial applications in drug delivery and gene and cell therapy.
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