Presented By: Biomedical Engineering
Biomedical Engineering Seminar Series
"Engineering Vascularized Human Myocardium for Heart Regeneration," with Kareen L. Coulombe, Ph.D.
Engineering Vascularized Human Myocardium for Heart Regeneration
Abstract:
Our mission in the Coulombe Lab is to advance cardiac regenerative medicine by engineering innovative therapies for heart disease patients around the world. Coronary heart disease and heart failure are major contributors to the global burden of cardiovascular disease, and their complexity demand a systems-engineering approach to heart regeneration. The Coulombe Lab for Heart Health and Regeneration develops engineered human myocardium (EHM) with cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) to restore cardiac muscle after myocardial infarction (MI) or in other disease states. We have developed clinically sized EHM implants for increasing cell dose up to 1 billion hiPSC-CMs and customized the hydrogel matrix, geometry and dynamic culture. EHM implantation in a translationally relevant swine model of chronic myocardial ischemia shows that engrafted hiPSC-CMs matured in vivo without inducing tachyarrhythmia. We also develop strategies for revascularization of the host heart and EHM implant through patterning mid-sized vessels in EHM and customization of angiogenic biomaterials, which are advancing regeneration. We are committed to empowering the next generation of scientists and engineers to implement their ideas for improving health and society through attentive mentoring, engaged scholarship, and active inclusion.
Bio:
Dr. Coulombe is an Associate Professor of Engineering and a member of the Institute for Biology, Engineering and Medicine at Brown University. She earned a B.S. in Biomedical Engineering at the University of Rochester summa cum laude in 2001 and was a Whitaker Pre-doctoral Fellow, earning a Ph.D. in Bioengineering at the University of Washington in 2007. She was an NIH Ruth L. Kirschstein post-doctoral fellow in Pathology at the University of Washington where she won an NIH Pathway to Independence K99/R00 award in 2012, and started her research program at Brown in 2014. She was inducted into the Athletic Hall of Fame at the University of Rochester in 2016; was named a Rising Star in 2017 by the Cellular and Molecular Bioengineering (CMBE) Group of BMES; was a Finalist for the Young Investigator Award at the Regenerative Medicine Workshop at Charleston (2019); was awarded a 2021 NSF CAREER Award; and was named as a 2021 Young Innovator of the CMBE. She lives in Pawtucket, RI with her husband and two daughters, and enjoys coaching lacrosse, creating art, and being in nature.
Zoom:
https://umich.zoom.us/j/94337625486
Abstract:
Our mission in the Coulombe Lab is to advance cardiac regenerative medicine by engineering innovative therapies for heart disease patients around the world. Coronary heart disease and heart failure are major contributors to the global burden of cardiovascular disease, and their complexity demand a systems-engineering approach to heart regeneration. The Coulombe Lab for Heart Health and Regeneration develops engineered human myocardium (EHM) with cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) to restore cardiac muscle after myocardial infarction (MI) or in other disease states. We have developed clinically sized EHM implants for increasing cell dose up to 1 billion hiPSC-CMs and customized the hydrogel matrix, geometry and dynamic culture. EHM implantation in a translationally relevant swine model of chronic myocardial ischemia shows that engrafted hiPSC-CMs matured in vivo without inducing tachyarrhythmia. We also develop strategies for revascularization of the host heart and EHM implant through patterning mid-sized vessels in EHM and customization of angiogenic biomaterials, which are advancing regeneration. We are committed to empowering the next generation of scientists and engineers to implement their ideas for improving health and society through attentive mentoring, engaged scholarship, and active inclusion.
Bio:
Dr. Coulombe is an Associate Professor of Engineering and a member of the Institute for Biology, Engineering and Medicine at Brown University. She earned a B.S. in Biomedical Engineering at the University of Rochester summa cum laude in 2001 and was a Whitaker Pre-doctoral Fellow, earning a Ph.D. in Bioengineering at the University of Washington in 2007. She was an NIH Ruth L. Kirschstein post-doctoral fellow in Pathology at the University of Washington where she won an NIH Pathway to Independence K99/R00 award in 2012, and started her research program at Brown in 2014. She was inducted into the Athletic Hall of Fame at the University of Rochester in 2016; was named a Rising Star in 2017 by the Cellular and Molecular Bioengineering (CMBE) Group of BMES; was a Finalist for the Young Investigator Award at the Regenerative Medicine Workshop at Charleston (2019); was awarded a 2021 NSF CAREER Award; and was named as a 2021 Young Innovator of the CMBE. She lives in Pawtucket, RI with her husband and two daughters, and enjoys coaching lacrosse, creating art, and being in nature.
Zoom:
https://umich.zoom.us/j/94337625486
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