Transcranial Focused Ultrasound Neuromodulation: from Brain to
Behaviors
Abstract:
Low-intensity transcranial focused ultrasound (tFUS) is an emerging technology that enables noninvasive modulation of neuronal activity with unprecedented precision through focused ultrasound waves. Despite its promising applications, our comprehension of the in-vivo neural mechanisms underlying this novel neuromodulation technology remains in its early stages. Our research endeavors in the lab aim to bridge this knowledge gap, extending from rodent to nonhuman primate models and humans. In my presentation, I will introduce some pivotal contributions made by our lab towards understanding the changes of in-vivo neuronal responses, inter-neuronal correlations, and brain network modulations elicited by tFUS stimulation. I will showcase our intracranial electrophysiological recordings from rodent and monkey models, revealing nuanced brain responses to specific stimulation parameters. Furthermore, we have translated tFUS devices and methodologies for the noninvasive modulation of human motor, somatosensory, and visual systems, measured through electroencephalography (EEG)-based source imaging with improved spatial specificity. Beyond influencing specific brain functions, I will also present our ongoing investigations into tFUS applications for modulating pain-related behaviors in a humanized sickle cell mouse model and for improving visual-motion responses and human cognitive attention in a brain-computer interface among a group of healthy human participants. These studies not only underscore the versatility of tFUS in neuromodulation but also highlight its therapeutic potential across domains of neurological function and behavior.
Zoom: https://umich.zoom.us/j/94337625486