Microdroplet chemistry has received increasing attention for accelerated reactions at the air/solution interface in recent years. This talk will discuss our progress toward microdroplet strategies which include (i) a voltage-controlled interfacial microreactor that allows acceleration of electrochemical reactions for the first time; (ii) novel interfacial reactions that address various long-standing isomeric problems in lipidomics; (iii) novel mass spectrometry imaging platform for cancer studies