Presented By: Biomedical Engineering
Biomedical Engineering Seminar Series
"Creating a Cellular “Google Map” of the Brain with Engineered Spatial Sequencing Technologies," with Yang Xiao, Ph.D.
Creating a Cellular “Google Map” of the Brain with Engineered Spatial Sequencing Technologies
Abstract:
Cells are not independent; they communicate and work synergistically in the brain. Unlike traditional approaches that rely on bulk assays, novel spatial technologies preserve the tissue's architecture at near single-cell resolution, allowing for more precise functional interpretation of the cell types and states. In this talk, I will introduce spatial proteomics and spatial epigenetics, two leading methods that enable in situ detection of proteins and open chromatin. Compared to spatial transcriptomics, spatial proteomics directly addresses key challenges in visualizing cellular morphology and evaluating whether RNAs are the best proxies for proteins. I will discuss how these approaches advance our understanding of brain function and disease, particularly in psychiatric disorders and traumatic brain injury.
Abstract:
Cells are not independent; they communicate and work synergistically in the brain. Unlike traditional approaches that rely on bulk assays, novel spatial technologies preserve the tissue's architecture at near single-cell resolution, allowing for more precise functional interpretation of the cell types and states. In this talk, I will introduce spatial proteomics and spatial epigenetics, two leading methods that enable in situ detection of proteins and open chromatin. Compared to spatial transcriptomics, spatial proteomics directly addresses key challenges in visualizing cellular morphology and evaluating whether RNAs are the best proxies for proteins. I will discuss how these approaches advance our understanding of brain function and disease, particularly in psychiatric disorders and traumatic brain injury.
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