Presented By: Department of Computational Medicine and Bioinformatics DCMB
Tools and Technology Seminar Presented by Yang Xiao
“Spatial Proteomics Reveals Cellular Neighborhoods in the Human Hippocampus”
Abstract
The human hippocampus plays a critical role in memory and emotion, with dysfunction implicated in numerous neuropsychiatric disorders. However, understanding its molecular pathology within the context of spatial architecture has remained challenging. This talk will introduce spatial proteomics as an emerging tool for dissecting complex cellular neighborhoods and their functions at single-cell resolution. It helped address two key problems in spatial transcriptomics: Can we detect cellular morphology? Are RNAs the best proxies for proteins? By utilizing 25-plex spatial proteomics through co-detection by indexing (CODEX), we established the experimental platform for profiling human hippocampus and developed a computational framework through the lens of cellular neighborhoods.
About The Tools & Technology Seminar Series
The DCMB Tools and Technology Seminar Series is held in Palmer Commons, Room 2036, each Thursday at 12pm EST. Each seminar highlights a computational tool, technology, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.
These seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel
The human hippocampus plays a critical role in memory and emotion, with dysfunction implicated in numerous neuropsychiatric disorders. However, understanding its molecular pathology within the context of spatial architecture has remained challenging. This talk will introduce spatial proteomics as an emerging tool for dissecting complex cellular neighborhoods and their functions at single-cell resolution. It helped address two key problems in spatial transcriptomics: Can we detect cellular morphology? Are RNAs the best proxies for proteins? By utilizing 25-plex spatial proteomics through co-detection by indexing (CODEX), we established the experimental platform for profiling human hippocampus and developed a computational framework through the lens of cellular neighborhoods.
About The Tools & Technology Seminar Series
The DCMB Tools and Technology Seminar Series is held in Palmer Commons, Room 2036, each Thursday at 12pm EST. Each seminar highlights a computational tool, technology, or methodology that is under development or in current use and is of special interest to DCMB and University researchers. Presenters are U-M researchers and students.
These seminars are live-streamed and recorded and made available for future viewing via the DCMB YouTube Channel
Related Links
Explore Similar Events
-
Loading Similar Events...
