Presented By: Biomedical Engineering
Biomedical Engineering Seminar Series
"Developing a novel in-silico tool for heterochiral macrocycle design," with Parisa Hosseinzadehi, Ph.D.
Developing a novel in-silico tool for heterochiral macrocycle design
Abstract:
Antibodies and small molecules have been powerful tools in targeting disease-related proteins. However, there remain many challenging targets—such as flat or featureless intracellular surfaces—that are often inaccessible to these modalities. This is where peptides come in. Peptides are particularly exciting because they can be synthesized via solid-phase methods, penetrate cells, and bind to flat protein interfaces that are otherwise undruggable. Despite this promise, designing effective peptides has remained a significant challenge. In our lab, we’re developing new computational and experimental tools to overcome these limitations. Today, I’ll be talking about CyclicCEA and CyclicMPNN, two current methods for rapid generation of Gly or Ala cycles. If time permits, I will also talk about their use as a binder design.
Abstract:
Antibodies and small molecules have been powerful tools in targeting disease-related proteins. However, there remain many challenging targets—such as flat or featureless intracellular surfaces—that are often inaccessible to these modalities. This is where peptides come in. Peptides are particularly exciting because they can be synthesized via solid-phase methods, penetrate cells, and bind to flat protein interfaces that are otherwise undruggable. Despite this promise, designing effective peptides has remained a significant challenge. In our lab, we’re developing new computational and experimental tools to overcome these limitations. Today, I’ll be talking about CyclicCEA and CyclicMPNN, two current methods for rapid generation of Gly or Ala cycles. If time permits, I will also talk about their use as a binder design.
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