Suicide is an extreme act, not a mental health disorder, which disproportionately impacts marginalized groups. In the U.S., most prevention focuses mainly on psychological distress, ignoring the patterns that emerge when considering the larger context of that tragic action. For Alaskan Native (AN) communities, youth suicide is a striking health inequity that arose within the past century, as colonization interrupted protective cultural resources and practices that shaped young people’s lives. Informed by decades of work with AN people, the presentation features studies from the Research to Practice Lab at ISR’s Research Center for Group Dynamics that illustrate a broader scope of suicide prevention interventions. These projects focus on family and community strengths, build onto local resources, and share evidence-based research and practices that participants can use on their own terms to reduce suicide risk and promote wellbeing. Highlighting innovation in both focus and outcome measurement, the interactive talk aims to generate questions, dialogue and ideas for addressing the complex issue of suicide.