Organ systems are composed of unique cell types that actively coordinate to enable higher order functions. Even slight deviances in the molecular or cellular states of these systems can result in debilitating disorders whose severity, treatment course, and overall treatment outcome vary widely from patient to patient. This level of complexity likely contributes to promising therapeutics failing within clinical trials and, thus, require further exploration. Thus, the Neumann lab focuses on developing and applying multimodal imaging and profiling techniques to study complex human diseases, such as renal cell carcinoma, Alzheimer’s Disease, and spina bifida. Beyond disease, we also develop methods for spatially assessing exogenous agents, including pharmaceuticals, toxins, and plastics, within organ and whole animal models.