The Sun lab is dedicated to exploring the dysfunction of RNA processing pathways to uncover the mechanisms of toxicity and the molecular basis of cell type-selective vulnerability in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Another major focus of the group is identifying disease modifiers using advanced functional genomic screening platforms. We aim to translate the mechanistic findings at molecular level into therapeutic target development to advance treatment strategies for neurodegenerative diseases.