Frameworks used to understand indigenous knowledges commonly view them as existing only in a particular place and community. The rapid growth of tribal museums and cultural centers striving to maintain local ways of knowing would support this view, however, these institutions have also played a significant role in negotiating between Native American and Euro-American approaches to knowledge. At the same time, national museums and Native American communities are working together to re-situate the intellectual heritage that is contained in museum collections, thereby negotiating the Euro-American use of indigenous knowledges. In this paper I use two examples from my research in Zuni–the development of the Zuni museum, and the history of the Zuni Ahayu:da created by Frank Hamilton Cushing–to argue the need for the multi-sited ethnography of North American indigenous knowledges. With growing concerns over the threats presented to traditional knowledges, I make the case for the use of frameworks that allow for the cross-cultural analysis of these intersections and institutions, thus giving insight into the complex dynamics of knowledge reproduction, maintenance and trans-cultural collaborations.