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Enabling Medicinal Chemistry with Synthesis and Technology

Aaron Beeler (Boston University)

In the Beeler Research Group we take a multidisciplinary approach toward developing small molecule tools for human disease. This lecture will focus on new technologies and synthetic strategies that provide a foundation for our medicinal chemistry programs. It will highlight ongoing efforts to develop platforms that enable us to explore and leverage the biological activities of complex natural products. A common theme in our lab, and in this lecture, is the use of flow chemistry to enable critical reactions. Why flow chemistry? Reactions have been carried out in batch vessels for over two centuries and amazingly the tools chemists use have remained largely unchanged. As such, many of the challenges presented by batch reactions are still unsolved. Issues related to mass transfer, heat transfer, or photon penetration can be exceptionally challenging in batch reactors, but are often overcome in flow. Ultimately, I hope to demonstrate how flow chemistry provides us a tool for development of new and more efficient reactions that are robust, highly scalable, and provide access to complex and novel chemotypes.



Aaron Beeler (Boston University)
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When and Where

Map Chemistry Dow Lab - CHEM 1640

December 2017

4:00pm - 5:30pm

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