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BME Seminar: Sharon Gerecht, Ph.D.

Thursday, Sept. 28, 2017
9:00 – 10:00 am
133 Chrysler

Sharon Gerecht, PhD
Professor and Kent Gordon Croft Investment Management Faculty Scholar ChemBE & DMES Director, the Institute for NanoBioTechnology
Johns Hopkins University

“Exploiting Physicochemical Cues to Guide Vasculature Differentiation and Assembly”


Vascular differentiation and formation (morphogenesis) takes place in an intricate milieu. This unique microenvironment is situated throughout the body in diverse types of healthy tissues, yet it seems to activates/inhibits similar mechanisms of the microvasculature. Two parameters of this microenvironment seem critical for blood vessel growth and stabilization: (i) the extracellular matrix (ECM), which provides critical support for vascular cell adhesion, proliferation, migration, and morphogenesis, and (ii) low oxygen concentrations (hypoxia), which is a critical factor promoting vascularization during embryonic development and tumor growth. In this talk I will present our recent efforts to understand how these physicochemical cues and downstream signaling pathways impact vascular fate and assembly from progenitors and pluripotent stem cells.
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When and Where

133 Chrysler

September 2017

9:00am - 10:00am

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