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Presented By: Bicentennial Office

Feast of Ideas

Amanda L. Garner, RNA: The Last Frontier in Drug Discovery

The central dogma is the hallmark of genetic transmission and molecular biology. The fundamental processing of DNA to RNA, via transcription, and RNA to protein, via translation, drives all cellular activities and its imbalance leads to disease. While efforts in drug discovery tend to take a more protein-centric view of the central dogma, whereby the great majority of approved drugs target proteins, through this presentation, Professor Garner will try to convince you that we’ve got it all wrong. In this presentation, she will describe new ways that U-M faculty are seeking to tackle this last frontier in drug discovery and decipher how to selectively target specific RNAs with small molecules for the treatment of human diseases.

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