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Presented By: Department of Physics

Quantitative Biology Seminar | The ParA/MinD Family of ATPases Make Waves to Position DNA, Cell Division, and Organelles in Bacteria

Anthony Vecchiarelli (U-M MCDB)

Positional information in eukaryotic cells is mainly orchestrated by cytoskeletal highways and their associated motor proteins like Myosin, Kinesin, and Dynein. Bacteria don't have motors, so how are they spatially organized? I will be discussing three members of the ParA/MinD family of ATPases that are part of self organizing systems that put things in their place in cells across the microbial world. I will first present the ATPase called ParA, which is part of the most common DNA-segregation system in bacteria. ParA proteins form dynamic waves on the nucleoid to position chromosomes and plasmids in opposite cell-halves so that they are faithfully inherited after cell division. I will then discuss the ATPase called MinD, which is part of a system that forms oscillatory waves on the inner membrane. The oscillation aligns cell division at mid-cell so that daughter cells are equal in size. Finally, I will introduce a new member of this ATPase family we call McdA, which is part of an organelle trafficking system in bacteria. Yes. Bacteria have organelles. Our work is shedding light on what seems to be a general mode of subcellular organization in bacteria – dynamic protein gradients surfing biological surfaces to impart positional information for a wide variety of fundamental biological processes. My new lab focuses on subcellular organization in bacteria with a strong emphasis towards reconstituting the self-organizing activities of these systems in a cell-free setup using purified and fluorescent labeled components. By visualizing the biochemistry driving self-organization outside the cell we are able to provide comprehensive molecular mechanisms that explain subcellular organization inside the cell.

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