We discuss the growth of cosmic structure as constrained using galaxy clusters from the 2500 deg2 South Pole Telescope SZ survey. The current sample contains 377 uniformly selected cluster candidates with Sunyaev-Zeldovich effect detection significance greater than five and redshift z>0.25. Of these, 89 also have Chandra X-ray data, and 32 have deep optical follow-up data used to measure the weak gravitational lensing shear. This multi-wavelength data set extends up to z~1.7, and allows for unique tests of astrophysics and cosmology beyond redshift 1.

In this talk, we will discuss the multi-wavelength analysis of the SPT-SZ cluster sample, simultaneously constraining cluster scaling relations and cosmology. After reviewing past and current results, we will discuss the next steps in the SPT cluster cosmology effort which will allow for even more powerful measurements of structure growth. These steps involve incorporating more weak lensing mass calibration data from different ground- and space-based facilities such as the Dark Energy Survey or the Hubble space telescope, as well as data from the next generations of CMB surveys.