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Presented By: Department of Chemistry

C-H and C-O functionalization via radical chaperones

David Nagib (The Ohio State University)

Our research is focused on harnessing the untapped reactivity of cheap and abundant chemical feedstocks in organic synthesis to enable the late-stage functionalization of complex natural products and other medicinally-relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These new radical chaperone strategies have enabled the development of chemical transformations with applications within molecules of biological and industrial interest.










David Nagib (The Ohio State University)

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