The Vaughan group develops new chemical tools for high resolution fluorescence microscopy and uses these tools, along with established ones, to understand the organization of biological systems with rich molecular detail. On the tool development side, we are synthesizing new fluorescent probes, creating new methods for tissue expansion and clearing, and developing assays to understand the organization of the genome. On the application side, we have partnered with biologists and pathologists to study the cytoskeleton, the organization of mouse and human kidney, and immune cell development. In my talk, I will discuss our recent work on the development and application of chemical tools for biological imaging.















Joshua Vaughan (University of Washington)