Antisocial behaviors, such as aggression and rule breaking, cause incredible costs to society and alter the trajectory of many young lives. In this talk, I will briefly describe work from my lab examining the role of parenting in the development of antisocial behavior. First, I will describe a series of studies we have done to examine the development of early callous-unemotional behaviors, a developmental risk factor for psychopathy. These studies show that callous-unemotional behaviors can be identified in the preschool period and that parenting interacts with genetic background to predict the development of callous-unemotional behaviors. Second, I will discuss our work linking parenting in early childhood to neural reactivity and risk for antisocial behavior in adolescence and adulthood. Throughout the talk, I will highlight the ways in which experience and genetic background interact to affect the development of the brain and behavior.