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LSA Biophysics pres.

Seminar Title: "Architecture and Molecular Control of Cell-Cycle Entry and Exit Pathways: A Live-Cell Tale of Phosphorylation, Transcription and Degradation "

Tobias Meyers, Mrs. George A. Winzer Professor in Cell Biology, Professor of Chemical and System Biology, Stanford University

Tobias Meyer Tobias Meyer
Tobias Meyer
Abstract: Mammals must regulate the proliferation of stem, progenitor and differentiated cells to build, maintain, and repair tissues. Control of cell-cycle entry and exit has been conceptualized by the restriction point, a time when cells escape the need for mitogens to complete the cell cycle. Our single-cell microscopy studies discovered instead two parallel and partially redundant pathways to enter the cell cycle out of quiescence and three pathways out of mitosis. In lieu of a sharp restriction point, we find a progressive stabilization of both increasing CDK4/6 and CDK2 activities when tested by mitogen removal or stress, a stabilization that ends with an irreversible commitment point driven by multiple positive feedbacks. I will delineate core principles, molecular mechanisms and timing of this fundamental cell-fate commitment whose abnormal regulation is a main cause for cancer.
Tobias Meyer Tobias Meyer
Tobias Meyer
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