Antimatter cosmic-ray measurements have long been used to advance our understanding of high energy astrophysical phenomena in the Galaxy. Using the antiproton cosmic-ray measurements by the Alpha Magnetic Spectrometer (AMS) on board the International Space Station, I will present work in search of unexpected sources of antiprotons. In doing that, I will discuss the uncertainties related to the interstellar propagation of cosmic-rays, the antiproton production cross-section uncertainties from inelastic cosmic-ray collisions the interstellar medium, as well as the uncertainties from the effects of the solar wind. At the GeV range there is an excess of cosmic-ray antiprotons that could be accounted for by a dark matter particle in the mass range of 50 to 90 GeV. Furthermore I will discuss the prospects of detecting anti-deuterons and anti-Helium nuclei produced both from inelastic collisions of high energy cosmic-rays with the interstellar medium gas from dark matter annihilations. Interestingly, under certain assumptions relating to the properties of the Milky Way we may be able to detect with AMS, cosmic-ray anti-deuterons and anti-Helium from annihilating dark matter particles.