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Chemical Regulation of Functional RNAs

Yunsun Nam (UT Southwestern Medical Center)

We study the mechanisms of specificity and regulation of enzymes that act on RNA. We identified the molecular basis for how a small molecule, heme, affects microRNA processing enzyme Drosha. We show that heme acts as a signaling factor to switch on processing of a subset of microRNAs. Other chemicals such as S-adenosylmethioinine, and transfer of its methyl group to RNA, can also have a big role in RNA-mediated gene regulation. We show the mechanistic details of how RNA methylation is accomplished, using crystal structures and biochemical studies.

Yunsun Nam (UT Southwestern Medical Center)
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When and Where

Map Chemistry Dow Lab - 1640 Chemistry

April 2019

4:00pm - 5:30pm

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