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Department of Materials Science and Engineering
University of Illinois at Urbana-Champaign

ABSTRACT
"Complexity in the chemistry and physics of lipid membranes as a handle to activate the delivery of cargo to cells"

Lipid materials having nanostructures that deviate from the conventional flat bilayer arrangement such as hexagonally packed lipid tubes and bicontinuous cubic phases are ubiquitous in nature. Their role remains elusive but over the years several pathologies and organelle functions have been coupled to lipid membrane structural complexity. In this talk we will discuss lipid membrane polymorphism and how it can be exploited to generate a new class of materials for the delivery of cargo to cells. We combine a number of techniques including X-ray scattering, cryo-EM, and cell culture to demonstrate that the structure of lipid nanoparticles is a powerful handle to boost the delivery of genes to cells. The simple argument that non-bilayer phases having intertwined nanoscale channels exist to increase surface-to-volume ratio might be insufficient to completely describe the experimental findings. We will show that synthetic lipid and lipid-polymer hybrid materials are able to capture many structural and dynamic properties seen in natural systems, when local heterogeneities and self-assembly out of equilibrium is taken into account.

BIO
Cecilia Leal is an Assistant Professor of Materials Science and Engineering and is affiliated with the Frederick Seitz Materials Research Laboratory at University of Illinois at Urbana-Champaign. She received a M.S. in Industrial Chemistry from the University of Coimbra in Portugal and a PhD in Physical Chemistry from the University of Lund in Sweden. Cecilia was a Swedish Research Council postdoctoral fellow in Materials Science at the University of California in Santa Barbara before she started her appointment at UIUC in 2012. Her research interests lie at the intersection of materials science and physical chemistry with a focus on soft materials relevant in biology. Cecilia is the recipient of a 2018 UIUC College of Engineering Dean's Award for Excellence in Research, the 2016 NSF CAREER Award, and the 2016 NIH Director’s New Innovator Award.

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