Our laboratory has embraced cooperative catalysis as a general framework for the design of new enantioselective reactions. Within this regime we have exploited cooperation between Lewis base and transition metal catalysts as an effective means to control and direct both reaction partners during bond construction. The versatility of this approach is such that each catalyst acts in an orthogonal manner, which permits the role and function of the metal center to be modified and tuned without compromising enantioselectivity. This seminar will describe our most recent efforts in asymmetric carbon–carbon and carbon-nitrogen bond formation.












Thomas Snaddon (Indiana University)