Quantitative Biology Seminar | Dynamics of intermittent neural synchronization: observations, mechanisms, and functions
Leonid Rubchinsky (Indiana University-Purdue University Indianapolis)
Synchronization of neural activity in the brain is involved in a variety of brain functions including perception, cognition, memory, and motor behavior. Excessively strong, weak, or otherwise improperly organized patterns of synchronous oscillatory activity may contribute to the generation of symptoms of different neurological and psychiatric diseases. However, neuronal synchrony is frequently not perfect, but rather exhibits intermittent dynamics. The same synchrony strength may be achieved with markedly different temporal patterns of activity. I will discuss methods to describe these phenomena and will present the application of this analysis to the neurophysiological data in healthy brain, Parkinson’s disease, and drug addiction disorders. I will finally discuss potential cellular mechanisms and functional advantages of some of the observed temporal patterning of neural synchrony.
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