Department of Physics pres.
Quantitative Biology Seminar | Pattern Formation and Self-organization in Biological Flows
Eleni Katifori (University of Pennsylvania)
In this talk we present how a biological transport network can utilise principles of self organization to develop and function. We first discuss how a hierarchically organized vascular system can develop under constant or variable flow and show how time-dependent flow can stabilize anastomoses and lead to a topology dominated by cycles. Next, inspired by haemodynamic fluctuations in the brain, we examine how networks can produce self-sustained oscillations in the flow even in the absence of varying external input. We discuss how these spontaneously emerging, self-organized fluctuations depend on the network topology, and how they can be modified by a controlled external input.
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