Presented By: Department of Chemistry
Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Heterocyclic Phosphonium Salt
Andy McNally (Colorado State University)
Selective methods that can functionalize electron-deficient heterocycles are in great demand due to their prevalence in biologically active compounds. Pyridines and diazines, in particular, are widespread components of pharmaceutical compounds yet methods to transform these motifs into valuable derivatives are still greatly sought after. We will present a selection of catalytic and non-catalytic methods using phosphorus intermediates that enable multiple new bond-constructions on these heterocycles. A particular emphasis will be placed on phosphorus ligand-coupling reactions that represent an alternative means to form CâC and C-Heteroatom bonds.
Andy McNally (Colorado State University)
Andy McNally (Colorado State University)
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