Due to the highly active radical intermediate, the organic transformation via radical pathway have been extensively studied. However, the selective control of radical intermediate is extremely challenging, which significantly retards the success of highly selective radical reaction, specially for the enantioselective version. Recently, Our group recently reveals that the stereoselective control of radical could be achieved by using copper catalyst, and a series of enantioselective difunctionalization of alkenes have been explored by using bisoxazoline (Box)/Cu(I) catalytic system. In these studies, a benzylic radical intermediate was involved in the catalytic cycles, which can be enantioselectively traped by (Box)/CuII intermediate to produce enantiomerically enriched products. In this talk, I'd like to introduced our recent progress in the asymmetric oxidative functionalization of C-H bonds, including benzylic and allylic C-H bonds, wherein copper catalyst plays important roles on the both site- and enantioselectivity.












Chaozhong Li(Shanghai Institute of Organic Chemistry) , Guosheng Liu(Shanghai Institute of Organic Chemistry)