Skip to Content


No results


No results


No results

Search Results


No results
Search events using: keywords, sponsors, locations or event type
When / Where
All occurrences of this event have passed.
This listing is displayed for historical purposes.

LSA Biophysics pres.

Biophysics Symposium

Professor Amy Keating, MIT Department of Biology and Biological Engineering

Protein-protein interactions among Bcl-2 family proteins regulate apoptosis. Anti-apoptotic members of the family, including Bcl-2, Bcl-xL, Bcl-w, Mcl-1, and Bfl-1, sequester pro-apoptotic family members by binding tightly to an amphipathic alpha helix within them, blocking pro-death functions. Through this mechanism, overexpression of the anti-apoptotic proteins is implicated in oncogenesis and resistance to chemotherapy. Tight-binding and selective inhibitors of Bcl-2 family proteins can be used to diagnose the Bcl-2 dependencies of cancer cells and may be developed as therapeutics. The challenge of designing peptides that function as high-affinity and selective inhibitors of specific Bcl-2 family proteins poses a fundamental, challenging problem in protein engineering and a good opportunity to study principles of protein-peptide recognition. I will describe features of Bcl-2 family protein interactions and discuss approaches we have developed that integrate computational structure-based modeling with high-throughput screening to generate peptide-based inhibitors.

Register here:

Explore Similar Events

  •  Loading Similar Events...
Report Event As Inappropriate Contact Event Organizers
Back to Main Content