Biomedical Engineering pres.
Ph.D. Defense: Mac Morris
Gaussian Mixture Model utilization for Classification of Deep Vein Thrombosis
Thrombosis was induced in 30 12-week-old mice divided into three groups and imaged at either acute, sub-chronic, or chronic time points. The multiparametric MRI volumes consisted of T1-, T2-, and T2-weighted images. The MRI volume for each mouse was normalized, and the thrombus was segmented. The T1, T2, and T2 intensities at each location were input into a Gaussian mixture model. Following image acquisition, tissue samples were acquired and stained for Martius scarlet blue trichrome to examine red blood cell, collagen, and fibrin content in each thrombus.
To analyze each Gaussian mixture model region, qualitative and quantitative analyses were performed by comparing the Gaussian mixture model results with the paired histology. 2D correlation values between the Gaussian mixture model tissue class and histological composition revealed that the first cluster class correlated with red blood cells (p < 0.05), and the second cluster class correlated with fibrin and collagen (p < 0.05). This study demonstrates that spatial correlations exist between the classification of multiparametric MRI data and corresponding histology. With the aforementioned methods and results from each study, we are able to move one step closer with assisting healthcare providers in optimizing treatments for patients with deep vein thrombosis.
Chair: Joan Greve
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