Abstract: Irregular changes in menstrual cycles and sex hormones signal a woman’s transition into menopause. Common health outcomes associated with this time period include: vasomotor symptoms, osteoarthritis, decreased bone mineral density, and increased cardiovascular risks. Current research examines the biological mechanisms that regulate this transition. However, further research is needed to determine the best methods for characterizing cyclic patterns of hormones in reproductive physiology.

Fitted representation of these hormones will contribute vital knowledge to the field of women’s health and wellness. This presentation will outline ongoing epidemiological analysis and elicit feedback on potential mechanisms, dynamic modeling, and parameterization of estradiol and follicle stimulating hormone across the menopause transition.