Presented By: Center for RNA Biomedicine
RNA Innovation Seminar, Luis Batista, Washington University in St. Louis
"Restoring tissue homeostasis in bone marrow failure syndromes via post-transcriptional modulation of TERC and U6 non-coding RNAs"
Luis Batista, PhD, Assistant Professor of Medicine and Developmental Biology, Washington University in St. Louis
Abstract: The overarching goal of the Batista lab is to understand the regulation and function of telomerase in tissue fitness, disease, and cancer. The Batista laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase dysfunction, using the targeted differentiation of human pluripotent stem cells to tissues of clinical relevance as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates to better understand the importance of correct ribonucleoprotein assembly and function in tissue fitness and to determine the events that lead from impaired RNA-protein assembly to disease in humans.
Abstract: The overarching goal of the Batista lab is to understand the regulation and function of telomerase in tissue fitness, disease, and cancer. The Batista laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase dysfunction, using the targeted differentiation of human pluripotent stem cells to tissues of clinical relevance as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates to better understand the importance of correct ribonucleoprotein assembly and function in tissue fitness and to determine the events that lead from impaired RNA-protein assembly to disease in humans.
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