Abstract: Bipolar disorder is characterized by recurrent mania and depressions. It is an illness of dynamic states and pathological changes in energy, emotion, and cognitions. The Prechter Bipolar Program studies the course and outcome of bipolar disorder from several vantage points and identifies 7 phenotypic sub-classes that contribute to the observed phenotype in a pluralistic manner. The classes include: disease, cognitive neuroscience (neuropsychology), psychology (personality), motivated behaviors, sleep and circadian, life story, and course / outcomes. Each of the phenotype sub-classes defines a scientific edge of research, each with contributions from several independent disciplines. The Prechter Bipolar Longitudinal Cohort consists over 1350 participants with clinical and biological data that will be available for collaborative research projects.