Dimensional models of psychopathology, that transcend diagnostic boundary, have gained traction within the clinical science literature as a means of overcoming the drawbacks of traditional psychiatric diagnostic systems. In this talk, I illustrate the ways in which my research program—aimed at understanding core dimensional factors of psychopathology—can transform clinical science research and practice. I additionally discuss how transdiagnostic dimensional models of psychopathology can inform understanding of health disparities among populations defined by marginalization and stigma.