Despite the promise for the use of chemical tools for investigating biological process and disease, many small molecule probes for most pathways/targets were unknown or unavailable until recently. Work in the Hopkins Laboratory centers around the synthesis and optimization of novel chemical tool compounds aimed at understanding biological processes and tackling unmet medical needs. This talk will cover two projects in my lab: 1. Synthesis and optimization of novel phosphodiesterase inhibitors as possible therapies for cocaine use disorders, and 2. The synthesis, optimization and biological characterization of a series activin receptor-like kinase 2 (ALK2) inhibitors for the treatment of rare and neglected diseases.
Corey Hopkins (University of Nebraska)