Synthetic iron-based catalysts that functionally model iron dependent oxygenases are rare. Considering the large number of synthetic iron complexes, why is this? We are taking a close look at this question and, in the process, have come up with some design principles that are guiding our work towards developing synthetic iron-based catalysts that use O2 as the oxidant. This work represents a major effort in our group towards sustainable chemistry by using earth abundant metals and oxidants that are non-toxic.









David Lacy (University of Buffalo)