I will discuss the status and future of calculations of nuclei based on the Standard Model of particle physics. With advances in supercomputing, we are beginning to quantitatively understand nuclear structure and interactions directly from the fundamental quark and gluon degrees of freedom. Recent studies provide insight into the neutrino-nucleus interactions relevant to long-baseline neutrino experiments, double beta decay, and theory predictions of dark matter cross-sections at underground detectors. I will also address new work constraining the gluonic structure of nuclei, which will be measurable for the first time at a future electron-ion collider, and explain how machine learning tools are providing new possibilities in this field.