Presented By: Center for RNA Biomedicine
RNA Seminar featuring: Elena Conti, Max Planck Institute of Biochemistry
TITLE: The RNA exosome complex: the Dr Jekyll and Mr Hyde of RNA degradation
KEYWORDS: molecular mechanisms, RNA, ribosome, biochemistry, cryo-EM, X-ray crystallography
ABSTRACT: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question.
ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ
ABSTRACT: All RNAs in eukaryotic cells are eventually degraded. The RNA exosome is a conserved macromolecular machine that degrades a vast number and variety of RNAs. Exosome-mediated RNA degradation leads to the complete elimination of nuclear and cytoplasmic transcripts in turnover and quality control pathways, and to the partial trimming of RNA precursors in nuclear processing pathways. How the exosome combines specificity and versatility to either eliminate or process RNAs has been a long-standing question.
ZOOM REGISTRATION REQUIRED: https://umich.zoom.us/webinar/register/WN_IjnWw1UcRkW8zcDeuAM2tQ
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