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Presented By: Department of Molecular, Cellular, and Developmental Biology

Molecular Basis of Inherited Parkinson’s disease

Suzanne Pfeffer, Stanford University

Suzanne Pfeffer Suzanne Pfeffer
Suzanne Pfeffer
Note: change in time to 1 PM

Abstract: Today more than 1 million people in the U.S. suffer from Parkinson’s disease, and although most cases are idiopathic,perhaps as many as 20% of cases have a genetic basis. We study the effect of mutations in the LRRK2 kinase that is the most frequent cause of inherited Parkinson’s. Pathogenic LRRK2 phosphorylates a subset of Rab GTPases that are
master regulators of membrane trafficking. We have discovered that Rab10 phosphorylation flips a switch on its function —phosphoRab10 bind an entirely new set of effectors that regulate the formation of primary cilia in cell culture and mouse brain. We are also studying regulation of LRRK2 by the PPM1H phosphatase and how loss of cilia could trigger Parkinson’s disease.

Host: Ming Li
Suzanne Pfeffer Suzanne Pfeffer
Suzanne Pfeffer

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April 9, 2021 (Friday) 1:00pm
Meeting ID: 91720907625

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