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Presented By: Biomedical Engineering

Master's Defense: Annie Taylor

Characterizing Dopamine Dynamics During Skilled Reaching Tasks

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Dopamine regulates motor performance and learning. Current models suggest that dopamine signals reward-prediction errors and/or movement vigor. These functions have been assessed predominantly using simple behavioral tasks. The role of dopamine in dexterous skill, however, is unknown. This question is important to understanding motor disorders such as Parkinson's Disease. Here we describe an experimental model to interrogate the role of dopamine release during learning and performance of dexterous skill. Fluorescent sensors dLight1.1 and GCaMP are used to monitor dopamine and calcium activity in the striatum and substantia nigra pars compacta (SNc) in rats performing skilled reaching tasks. Preliminary experiments have successfully recorded reward-associated signals in both striatum and SNc. Adaptations to the recording setup to facilitate long-term recording in larger rodents are described. These results demonstrate the viability of fiber photometry for measuring dopamine-related activity during skilled reaching tasks.



Date: Wednesday April 21, 2021

Time: 10:30 AM

Zoom: https://umich.zoom.us/j/96449273959

Chair: Dr. Dan Leventhal
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April 21, 2021 (Wednesday) 10:30am
Meeting ID: 96449273959

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