Skip to Content


No results


No results


No results

Search Results


No results
Search events using: keywords, sponsors, locations or event type
When / Where
All occurrences of this event have passed.
This listing is displayed for historical purposes.

Presented By: Biomedical Engineering

Master's Defense: Annie Taylor

Characterizing Dopamine Dynamics During Skilled Reaching Tasks

BME Logo BME Logo
BME Logo
Dopamine regulates motor performance and learning. Current models suggest that dopamine signals reward-prediction errors and/or movement vigor. These functions have been assessed predominantly using simple behavioral tasks. The role of dopamine in dexterous skill, however, is unknown. This question is important to understanding motor disorders such as Parkinson's Disease. Here we describe an experimental model to interrogate the role of dopamine release during learning and performance of dexterous skill. Fluorescent sensors dLight1.1 and GCaMP are used to monitor dopamine and calcium activity in the striatum and substantia nigra pars compacta (SNc) in rats performing skilled reaching tasks. Preliminary experiments have successfully recorded reward-associated signals in both striatum and SNc. Adaptations to the recording setup to facilitate long-term recording in larger rodents are described. These results demonstrate the viability of fiber photometry for measuring dopamine-related activity during skilled reaching tasks.

Date: Wednesday April 21, 2021

Time: 10:30 AM


Chair: Dr. Dan Leventhal
BME Logo BME Logo
BME Logo

Livestream Information

April 21, 2021 (Wednesday) 10:30am
Meeting ID: 96449273959

Explore Similar Events

  •  Loading Similar Events...
Report Event As Inappropriate Contact Event Organizers
Back to Main Content