Research on racism and health is critical to optimizing the mental health and wellness of Black American young people. Through research that integrates psychology, biology, developmental and family science, and public health, we have: 1) advanced our understanding of racism experiences among Black American youth; 2) delineated mechanisms that mitigate or exacerbate the mental health sequelae of racism; and 3) tested a biopsychosocial model of racism-related stress to identify opportunities for intervention and the eradication of racism. In this presentation, I will highlight recent key findings and reflect on the value of combining racism, public health, and clinical science to inform the next generation of research, alleviate the health consequences of racism, and promote health equity for Black and other marginalized youth.