BME 500 Seminar Series
Jason Locasale, Ph.D.
Pharmacology and Cancer Biology
Duke University

"Diet and metabolic therapeutics in cancer metabolism"
Abstract:
This presentation will focus on methionine metabolism in health and cancer. I will first
discuss methionine content in human food and dietary patterns . I will next focus on
how changes to dietary methionine can produce defined consequences on cellular
metabolism. I will then discuss work on dietary influences on the activity of the
pathway and its relation to the regulation of one carbon metabolism in cancer. How
methionine restricted diets may allow for interventions in cancer treatment and relevant
mechanisms will be discussed including how changes to dietary methionine can
influence interventions that target one carbon metabolism involving radiation and
antimetabolite chemotherapies such as 5-fluorouracil. The link between nutritional
methionine status and chromatin biology and epigenetics will also be introduced in this
talk.
Details:
DATE: Thursday, November 11, 2021
TIME: 4:00-5:00 pm
ZOOM LINK: https://umich.zoom.us/j/97723483179