Presented By: Applied Physics
Applied Physics Seminar: "The membrane phase transition and its impact on plasma membrane structure and function"
Sarah Veatch, Associate Director, Department of Biophysics, Associate Professor of Biophysics and Associate Professor of Physics, College of Literature, Science, and the Arts, University of Michigan
Abstract:
Plasma membranes can separate into two coexisting liquid phases when isolated from cortical cytoskeleton although phase separation is not detected in intact, living cells. This presentation will highlight our recent work to demonstrate that the membrane phase transition contributes to the organization, dynamics, and signaling activity of proteins at B cell receptor clusters. I will also present our recent theoretical work examining emergent properties of polymer rich droplets at heterogeneous membranes, making predictions for how liquid-liquid phase separation in the cytoplasm of cells could couple to the distinct phase transition at the plasma membrane.
Plasma membranes can separate into two coexisting liquid phases when isolated from cortical cytoskeleton although phase separation is not detected in intact, living cells. This presentation will highlight our recent work to demonstrate that the membrane phase transition contributes to the organization, dynamics, and signaling activity of proteins at B cell receptor clusters. I will also present our recent theoretical work examining emergent properties of polymer rich droplets at heterogeneous membranes, making predictions for how liquid-liquid phase separation in the cytoplasm of cells could couple to the distinct phase transition at the plasma membrane.
Explore Similar Events
-
Loading Similar Events...
