197 countries have signed the Paris Agreement - the global framework to limit global warming to 1.5C and address the already-present and future impacts of climate change. The best available science informs the policy discourse through a periodic review of the long-term temperature goal and requests to the Intergovernmental Panel on Climate Change to develop reports of interest. In light of the upcoming publication of the 6th Assessment Report of the IPCC, this talk will review the current state of scientific knowledge of climate change touching on all three of its Working Groups: physical science, impacts and adaptation, and mitigation, including the role that nuclear power plays in scenarios assessed by WGIII. Particular focus will be given to how the science-policy interface informs negotiation processes including the yearly Conference of Parties, setting of national policy targets such as Nationally Determined Contributions and net zero targets, and the upcoming Global Stocktake.