Abstract:
Ultrasound imaging and therapy have been increasingly important in disease diagnosis, treatment guidance, treatment and post treatment assessment. In this talk, novel small aperture ultrasound transducers are presented for advanced intravascular ultrasound imaging (IVUS), intravenous sonothrombolysis, localized tissue ablation and drug delivery. In specific, high frequency (40-60 MHz) micromachined piezoelectric composite transducers and arrays with broad bandwidth (-6 dB fraction bandwidth of ~ 80%) were developed and integrated into 3-Fr catheters for intravascular ultrasound (IVUS) imaging. Dual frequency transducers and arrays (6.5 MHz/30 MHz, 3 MHz/30 MHz) were also successfully demonstrated for contrast enhanced intravascular superharmonic imaging (or acoustic angiography) toward detection of plaque vulnerability. For the case of intravenous thrombolysis, small aperture (diameter <2 mm) sub-MHz forward-looking transducers were successfully demonstrated, in-vitro, for microbubbles/nanodroplets-mediated sonothrombolysis. Other transducer techniques such as small aperture high intensity focused ultrasound (HIFU) transducers, laser ultrasound transducers and dual-mode transducers were also investigated for localized tissue ablation, drug delivery and intravascular sonothrombolysis. Finally, challenges and future perspectives of ultrasound transducers are discussed for advanced ultrasound imaging, therapy, and drug delivery.

Biography:
Dr. Xiaoning Jiang is a Dean F. Duncan Distinguished Professor of Mechanical and Aerospace Engineering and a University Faculty Scholar at North Carolina State University. He is also an Adjunct Professor of Biomedical Engineering at North Carolina State University and University of North Carolina, Chapel Hill, and an Adjunct Professor of Neurology at Duke University. Dr. Jiang received his Ph.D. degree from Tsinghua University (1997) and his postdoctoral training from the Pennsylvania State University (1997-2001). He was the Chief Scientist and Vice President for TRS Technologies, Inc. prior to joining NC State in 2009. Dr. Jiang is the author and co-author of two books, six book chapters, nine issued US Patents, 150 peer reviewed journal papers and over 120 conference papers on piezoelectric ultrasound transducers, ultrasound for medical imaging and therapy, drug delivery, ultrasound NDT/NDE, smart materials and structures and M/NEMS. Dr. Jiang serves as the Vice President for Technical Activities of IEEE Nanotechnology Council (2022 and 2023), an editorial board member for the journal Sensors, and a Senior Associate Editor for the ASME Journal of Engineering and Science in Medical Diagnostics and Therapy. Dr. Jiang was an IEEE NTC Distinguished Lecturer in 2018 and 2019, Co-EIC of IEEE Nanotechnology Magazine (2020 and 2021), and he is an ASME Fellow and a SPIE Fellow.

Zoom Link: https://umich.zoom.us/j/96508834308

Organized by:
Dr. Brendon Baker,
Assistant Professor, Biomedical Engineering

Dr. David Nordsletten,
Associate Professor, Department of Biomedical Engineering and Cardiac Surgery